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Case Reports

Abstract

Cutaneous myxomas, also known as superficial angiomyxomas, are uncommon benign hamartomatous neoplasms often presenting as a singular lesion on the trunk, head and neck, or genital region.  Multiple cutaneous myxomas in conjunction with other systemic findings may occur in the setting of Carney Complex or its subsets, NAME and LAMB syndromes. Histolologically, cutaneous myxomas are characterized as a well-circumscribed dermal or subcutaneous proliferation of variably sized fibroblasts and stellate cells within a mucinous matrix with prominent branching capillaries. An uncommon histopathologic feature demonstrated in the present case was notable follicular induction overlying the biopsied lesion. Follicular induction is a phenomenon by which primitive hair follicles and associated sebaceous glands are produced by the epithelium due to the influence of an underlying inflammatory or neoplastic dermal process. Most commonly appreciated in other benign entities such as dermatofibromas, follicular induction can be mistaken for basal cell carcinoma due to the presence of basaloid proliferations which can resemble a neoplastic process histologically in superficially sampled lesions. This case seeks to highlight the occurrence of follicular induction in cutaneous myxomas and provide a review of its presence in other benign neoplasms, helping to avoid misdiagnosis as a malignant neoplasm.