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Case ReportsAbstract
Epidermodysplasia verruciformis (EV) is a rare genetic disorder transmitted in an autosomal recessive manner, characterized by increased susceptibility to specific human papillomavirus (HPV) subtypes. It presents with flat warts, papules, or plaques that can become malignant. We present a case of a 25-year-old male with an 8-year history of progressively worsening brownish-red plaques on the face and body. Laboratory tests for HPV types 6, 11, 16, 18, 32, 33, 35, 39, 45, 51, 52, and 59 were negative. Histopathology revealed hyperkeratosis, a basket-weave pattern of the stratum corneum, acanthosis, and vacuolated cells with pale blue cloudy cytoplasm, confirming the diagnosis of EV.