Abstract
A 55-year-old woman presented to the outpatient dermatology clinic for a three-year history of a painless growth on the oral buccal mucosa that had recently increased in size and was interfering with mastication. She was otherwise healthy and had no history of similar lesions. On exam a 1 cm mucosa-colored nodule was noted on the left buccal mucosa in the bite line. After administration of local anesthesia, the lesion was biopsied using a Kelly clamp and gradle. H&E staining revealed glycogenic acanthosis of the mucosal epithelium with fibrosis of the dermis. Glycogenic acanthosis is a common benign epithelial thickening typically found incidentally on upper endoscopy in the mid to lower esophagus. The etiology of esophageal glycogenic acanthosis is unknown but has been found to be associated with hiatal hernia. Glycogenic acanthosis in the oral cavity has rarely been reported and those cases were associated with underlying disease such as HIV and Cowden syndrome. Notably, in reported cases of oral glycogenic acanthosis, clinical lesions were described as a white plaque. To our knowledge, this is the first reported case of oral glycogenic acanthosis presenting as a mucosa-colored nodule.
Financial Disclosure:
No current or relevant financial relationships exist.