Track: Clinical Studies

Topic: Melanocytic Neoplasms

Abstract:

Background: Spitz Nevus, often mistaken for malignant melanoma due to histological similarities, poses a diagnostic challenge in dermatology. This rare melanocytic lesion, characterized by spindle and/or epithelioid cells, typically displays rapid initial growth followed by stabilization or spontaneous regression. Its diagnosis is complicated by its resemblance to melanoma, necessitating a deeper understanding and accurate differentiation between the two.

Method: In a retrospective descriptive study conducted at an academic hospital over five years (2016–2021), patients diagnosed with Spitz Nevus through biopsy were analyzed. Data on patient demographics, clinical presentation, and histopathology were collected from medical records and subjected to statistical analysis using SPSS software.

Result: The study included 86 patients, with a slight female predominance (55.5%) and an average age of 15.6 years. Lesions were most commonly found on the upper limbs (23.3%) and face (17.4%). Compound Spitz Nevus was the most prevalent histopathological type (29.4%), followed by Junctional (16.5%) and Dermal Spitz Nevus (11.8%). These findings align with previous reports, highlighting the lesion's clinical and histopathological diversity and emphasizing the importance of accurate diagnosis and differentiation from melanoma.

Conclusion: This study offers valuable insights into the demographics, clinical presentation, and histopathology of Spitz Nevus, underscoring the need for precise diagnostic techniques to distinguish it from melanoma. Further research, including molecular and immunohistochemical analyses, is warranted to enhance understanding and management, ultimately improving diagnostic accuracy and patient care in dermatology.

Kambiz Kamyab

Affiliation

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(442) Study of the Demographics, Clinic, and Pathology of Biopsied Patients with Spitz Nevus in Five Years