Abstract:

Nodular cutaneous amyloidosis is a rare form of cutaneous amyloidosis characterized by deposition of amyloid fibrils and plasma cell infiltrates in the head, trunk, or extremities. We present a case of a 65-year-old woman with nodular amyloidosis and a history of systemic sclerosis. The patient presented with a 2-cm waxy nodule on the right lower leg. Biopsy of the lesion revealed a perivascular inflammatory infiltrate with predominantly lambda-restricted plasma cells containing cytoplasmic globules. Amorphous eosinophilic deposits are diffuse throughout the dermis, and superficial subcutis. Subsequent workup including urinalysis, serum protein electrophoresis, and urine electrophoresis failed to reveal evidence of systemic amyloidosis. Although uncommon, up to 15% of patients with nodular amyloidosis may develop systemic amyloidosis. Histopathologic findings in nodular amyloidosis cannot be distinguished from those of systemic amyloidosis, therefore clinical and laboratory evaluation is necessary to exclude systemic amyloidosis.

Financial Disclosure:
No current or relevant financial relationships exist.

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EVELYN ILORI, MD, PHD