Abstract:

Primary cutaneous adenosquamous carcinoma is an uncommon malignant neoplasm with an inclination for invasion, local recurrence, and aggressive clinical course. Typically regarded as a high-grade variant of squamous cell carcinoma, this neoplasm displays mixed squamous and glandular elements. The most frequent locations for this malignancy are the head and neck. We describe a case of cutaneous adenosquamous carcinoma in an elderly woman with history of cardiomyopathy, chronic kidney disease, and multiple myeloma treated with chemoradiation who presented with five cutaneous lesions which were biopsied. One of these lesions, a pink and indurated plaque on the back, displayed a proliferation of atypical keratinocytes arranged in disperse cords, strands, and nodules on histology. Some of these cells showed ductal differentiation, expressing CEA on immunohistochemical stains. Mucicarmine highlighted mucin present in the ducts . The squamous areas expressed CK5/6, p63, and EMA and thus the diagnosis of adenosquamous carcinoma was rendered. Recognition of this entity is crucial as it frequently recurs and is often seen in immunocompromised patients.

Financial Disclosure:
No current or relevant financial relationships exist.

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Stanton Miller, MD