Abstract:

Cutaneous cribriform carcinoma is an unusual and extremely rare variant of apocrine carcinoma. Cases in the literature are most often presented as single case reports with rare case series. We report three cases of this entity to add to the body of literature. All three cases were of long-standing duration, submitted as dermatofibromas and presented on extremities. None of the patients carried an antecedent medical diagnosis of malignancy elsewhere. Histopathologically the carcinomas have a striking cribriform arrangement with the neoplastic aggregations consisting of both solid and tubular structures with the composite cells having large nuclei and abundant eosinophilic cytoplasm with decapitation secretion on luminal surfaces. Since primary cutaneous cribriform carcinoma appears to be locally destructive, but does not metastasize, it is critical to recognize these neoplasms and to differentiate them from their more lethal counterparts in other organs.

Financial Disclosure:
No current or relevant financial relationships exist.

Menu

Daiva Mattis, MD, PhD

Biography