(484) Rapid Squamous Cell Carcinoma Progression in a Liver Transplant Recipient

Track
Case Reports
Abstract

Solid organ transplant recipients (SOTRs) have an increased risk of non-melanoma skin cancer (NMSC). Sun exposure, smoking, concomitant viral infection, and immunosuppression contribute to the development of malignancies in SOTRs. There is limited literature available on liver transplant patients compared to those who have undergone other types of transplants. A 57-year-old man with a history of diabetes and a liver transplant caused by nonalcoholic steatohepatitis in 2019 presented with a non-healing, exophytic, and ulcerative lesion on the right lower lid. Multiple biopsies performed by an oculoplastic surgeon showed only caseous necrosis, and the patient was then referred to dermatology.  Stains and cultures were negative for infectious organisms, and an incisional biopsy confirmed the diagnosis of squamous cell carcinoma. Capecitabine, acitretin, and 5-fluorouracil injections slowed tumor growth while imaging studies were being conducted.  The tumor was confined to the orbit, and a multispecialty surgical team removed the eye and tumor and began reconstruction. We present this case to emphasize the importance of collaboration between different specialties in following up on SOTRs.

Published in: ASDP 61st Annual Meeting

Publisher: The American Society of Dermatopathology
Date of Conference: November 4-10, 2024