Track

Clinical Studies

Abstract

Background: Pemphigus foliaceus is a chronic autoimmune illness characterized by superficial blisters and skin erosion. Demographic and clinical criteria often vary in patients, making the management and understanding of the illness complicated. This cross-sectional review was evaluated to compare the demographic and clinical criteria of Pemphigus Foliaceus across different ages.

Methods: We analyzed data from 122 cases with Pemphigus Foliaceus who were referred to our Hospital. An analysis, chi-square, Fisher's exact test, independent t-test, Mann-Whitney test, Likelihood Ratio Test, and Valis Crusher Test were employed to examine the associations between variables. This analysis focused on variables like age, gender, residence, PDAI scores, and skin erosion locations. SPSS 26 was used for statistical evaluation.

Results: Patients ranged from 1 to 83 years, with a higher prevalence in the 40-60 age bracket. Women were most affected, in 30-40 age group. Most cases had a PDAI-Total-Activity-Score <15 during their first admission. Significant variations in PDAI scores and skin erosions were presented across all age groups and body parts. Notably, 20-30 age group exhibited higher disease progression. Also, metabolic disorders like hyperlipidemia and diabetes were found in some patients.

Conclusion: Our study found significant demographic and clinical characteristics in Pemphigus Foliaceus cases between age categories. Younger adults (20-30 years) had disease with more severity, while different skin erosion patterns suggested different disease behaviors in various ages and body parts. These factors emphasize the necessity for age-specific management strategies and further investigation into pathophysiology of Pemphigus foliaceus in different demographic