Abstract

Dermatofibromas are commonly occurring cutaneous soft-tissue lesions that arise from a benign proliferation of fibroblasts. They most often develop independently, but can be associated with several systemic conditions or skin tumors. Squamous cell carcinomas are commonly occurring cutaneous malignancies with a variety of different clinical presentations. They tend to arise most often in areas of prior ultraviolet radiation exposure, but can also have multiple other etiologic associations. To the best of our knowledge, squamous cell carcinoma has only once been previously described in association with a dermatofibroma in the literature, and this was as an in-situ lesion. Herein, we describe the clinical and pathologic findings of a 64-year-old female with an invasive, high-risk squamous cell carcinoma arising in association with a giant dermatofibroma. In addition, we hypothesize potential mechanisms for this rare cutaneous phenomenon.

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